Comfort mouse for large hands. Benefit from smarter scrolling, more comfort, and increased productivity. The Signature M650 features SmartWheel scrolling: scroll with utmost precision or high speed, depending on your needs at the moment. Choose the Signature M650 that best suits you. We recommend the M650 for small to medium hands, the M650 L for large hands, and the M650 L left for left-handed users. Working with your Signature M650 will bring you great joy. All mice are characterized by their contoured shape, a soft thumb area, and rubberized side grips, ensuring the mouse always sits securely in your hand. Enjoy more comfort and focus on your tasks.