
ASUS Xonar U5
USB
ASUS Xonar U5
USB
According to the manufacturer, yes it is compatible :)
I use this external sound card with a 2.1 system from Bose. The manual describes how to connect a 5.1 system by connecting the subwoofer to the centre socket: https://dlcdnets.asus.com/pub/ASUS/Audio_Card/Xonar_U5/E11117_Xonar-U5_Guide_v2_web_only.pdf